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It has been suggested that SGLT2-i could exert a RAS-inhibition-like effect, without being associated with a real RAS-suppression

Someone with higher body fat may see more visible changes while someone already lean typically experiences subtle refinements better abdominal definition smoother transitions between muscle groups and reduced water retention

Push it too far and you get the nausea, vomiting, and constipation that make the first few weeks of GLP-1 therapy so challenging

Our literature search identified one prior systematic review and meta-analysis with tirzepatide that included four RCTs (2783 participants) [26]

For context, semaglutide and tirzepatide typically see 4-7% discontinuation rates due to adverse events in their trials